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KMID : 0370220210650010017
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Yakhak Hoeji
2021 Volume.65 No. 1 p.17 ~ p.22
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Strain, Age, and Gender Differences in Response to Lipopolysaccharide (LPS) Animal Model of Sepsis in Mice
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Gahima Ivan
Twizeyimana Eric
LuckGonzales Edson
Remonde Chilly Gay
Jeon Se-Jin
Shin Chan-Young
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Abstract
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Sepsis is an excessive and irregular host response against existing infection, wherein pathogen invasion isprimarily responsible for the resulting damage. However, sepsis-related damage is substantially caused by excessiveuncontrolled host response. The purpose of this study was to investigate the differences in immune response based on thestrain, age, and sex of mice by examining the survival rate and latency following immune challenge. The results showedthat there was no significant difference between strains (ICR and C57BL6) following lipopolysaccharide (LPS) treatment.
Adolescent male mice (8 weeks old) had a higher survival rate and longer latency to death compared to those of adultmice (13 weeks old) following LPS treatment. Moreover, the onset of death in adolescent mice occurred substantially latercompared to that in adult mice. Females displayed longer latency to death and higher survival rates compared to their malecounterparts following immune challenge. Thus, the differences in survival rate and latency between young and adult miceand between male and female might contribute to age- and sex-specific adaptive host immunity, respectively. Our findingshighlight the importance of considering the age, sex and strain of animals in experimental models of sepsis and providea rationale to evaluate susceptibility in specific designs of sepsis immunotherapy. The clinical relevance of this studyawaits further studies.
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KEYWORD
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Lipopolysaccharides, Sepsis, Survivability, Gender, Age
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